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    Multiple urinary biomarkers may help detect male infertility

    This study suggests five urinary biomarkers can be useful in in diagnosing infertility in men. The potential biomarkers from this study are expected to help researchers develop a test that screens for normozoospermic infertility, a condition that existing tests typically do not defect. http://pubs.acs.org/doi/abs/10.1021/pr5003142?source=cen

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    Salivary biomarkers of Type-2 Diabetes Risk in Children

    The epidemic of obesity in America is staggering and the costs of treating the diseases associated with being overweight are increasing. The prevalence of pediatric Type-2 diabetes (T2D) is particularly troubling since there has been a marked increase in frequency. Early intervention can reverse or prevent some of the more serious side-effects of the disease […]

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    Inflammatory Proteins Hold Promise as Early Predictors of Psychosis

    Researchers at Johns Hopkins University published data suggesting that a panel of inflammatory proteins measured in blood may be useful in identifying changes that are characteristic of psychotic conditions. While more research is needed, these markers, including α2M, fibrinogen, IL-6R, SCF, TGFα, TNFR2, IL-8 and MCP-2/CCL8, have potential utility as early predictors of psychosis and […]

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    Recorded Webinar: Standardized Assays for Personalized Immune Response Monitoring

    If you were unable to attend the webinar or would like to view the webinar again, a recorded version is now available for your convenience. This online seminar provides an overview of research published in Immunity that demonstrates progress in the standardization of assays for personalized immune response monitoring. https://rbm.myriad.com/scientific-literature/webinars/standardized-assays-for-personalized-immune-response-monitoring/

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    Biomarkers for a new cancer immunotherapy drug

    This month’s paper features the results of a Phase I study on a new cancer immunotherapy drug. VTX-2337 is a toll-like receptor 8 agonist, activating a part of the innate immune system to stimulate a response that promotes anti-tumor activity. Here, biomarker data is shown that supports activation of the TLR8 pathway and the authors […]

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    Inflammatory and metabolic biomarkers indicate colorectal cancer (CRC) risk

    A study recently published in the European Journal of Epidemiology evaluated the correlation of colorectal cancer risk and biomarker patterns of inflammatory and metabolic pathways. The researchers concluded that several markers, including adiponectin, C-reactive protein (CRP), and leptin, are associated with CRC development. http://www.ncbi.nlm.nih.gov/pubmed/24791703

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    The Importance of Sample Handling and Curation

    Careful sample handling is critical to maintaining the long term value of legacy samples. Strict protocols and processes are essential to the curation of samples for future study. http://www.genengnews.com/gen-articles/managing-the-past-for-future-benefit/5193/

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    A New Generation of Biomarkers for Detecting Early Signs of Kidney Damage

    Nephrotoxicity is a major problem in the preclinical and clinical setting that results in the failure of candidate compounds throughout the drug-development cycle. An article in this month’s GEN outlines the development of a new generation of biomarkers for drug-induced toxicity that provides greater sensitivity and earlier detection than previous methods. http://www.genengnews.com/gen-articles/fighting-kidney-toxicity-the-case-for-better-biomarkers/5178/

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    S100A12 (EN-RAGE) Correlates with Poor Outcome after Ischemic Stroke

    Researchers published data illustrating the potential utility of S100A12 (EN-RAGE) as a predictive biomarker of functional outcome after ischemic stroke. While further studies are needed, increased plasma levels of EN-RAGE were shown to correlate significantly with increased risk of poor functional outcome. http://www.sciencedirect.com/science/article/pii/S0022510X14001361

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    Biomarkers of Concussion May Speed Diagnosis

    Traumatic brain injuries and concussions are rather common in contact sports, resulting in a variety of symptoms including dizziness, headaches, nausea, and sometimes loss of consciousness. The long-term effects of concussions are still being studied but researchers believe that cumulative blunt force trauma over a career may result in serious neurological conditions later in life. […]

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