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    Pharmacodynamic biomarkers for Apremilast treatment in psoriatic arthritis

    A new paper from Peter Schafer, et al, of Celgene shows how biomarkers can be used to monitor treatment response in an inflammatory disease setting. The early timepoints show a dose-dependent biomarker response while the later timepoints show a more normalized response, possibly correlated with reduced disease severity. Read Paper »

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    ENRAGE: A Novel Inflammatory Marker for Incident Coronary Heart Disease

    This recent paper in the Arteriosclerosis, Thrombosis and Vascular Biology Journal of the American Heart Association describes an interesting prospective study of 839 coronary heart disease (CHD)-free individuals who were followed for about 10 years with blood based biomarker testing. As the mean age at the beginning of the study was 73 years, 99 individuals […]

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    Blood-based proteins are crucial to the development of biomarker tests aimed at improving the diagnosis and treatment of psychiatric disorders

    A recent review of studies measuring proteins in blood serum/plasma illustrates the systemic nature of disease-related changes in patients with schizophrenia, major depressive and bipolar disorders. The collection of studies examined, including many that utilized Myriad RBM’s services, underscores the importance of including analysis of these peripheral proteins in the development of validated biomarker tests […]

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    Biomarker signatures predict clinical outcomes in metastatic colorectal cancer (mCRC) patients treated with chemotherapy and cediranib

    Researchers sought to explore biomarkers in pre- and on- treatment mCRC patients receiving chemotherapy with and without cediranib, in order to identify patient subgroups who may benefit from the combination cediranib therapy. http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2014436a.html

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    Vitamin D Binding Protein in serum demonstrates utility as a biomarker of Alzheimer’s disease

    Researchers at the University of Texas Health Science Center, San Antonio used a Multiple Indicators Multiple Causes (MIMIC) approach to evaluate the correlation between serum Vitamin D binding protein (VDBP) levels and cognitive performance in Alzheimer’s patients. While further studies are needed, this research suggests that increased levels of serum VDBP may be helpful in […]

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    Blood-based proteins help elucidate mediators of cognitive impairment in Late Life Depression (LLD)

    Researchers from the University of Pittsburgh analyzed 242 proteins in conjunction with structural brain abnormalities to identify biological mechanisms that contribute to cognitive impairment in patients with LLD. A panel of proteins, consisting primarily of proteins involved in immune response, cell signaling and inflammation, were determined to help differentiate LLD patients with mild cognitive impairment […]

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    Biomarkers enhance prediction of cardiovascular events when added to clinical risk factors in the ORIGIN trial

    Measuring large numbers of biomarkers in blood with new assay technologies may identify new biomarkers and physiologic pathways for cardiovascular events in people with dysglycemia and improve the ability of clinical risk factors to identify susceptible individuals. http://ADA.apprisor.org/index.cfm?k=uaofuc07uy

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    Multiple urinary biomarkers may help detect male infertility

    This study suggests five urinary biomarkers can be useful in in diagnosing infertility in men. The potential biomarkers from this study are expected to help researchers develop a test that screens for normozoospermic infertility, a condition that existing tests typically do not defect. http://pubs.acs.org/doi/abs/10.1021/pr5003142?source=cen

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    Salivary biomarkers of Type-2 Diabetes Risk in Children

    The epidemic of obesity in America is staggering and the costs of treating the diseases associated with being overweight are increasing. The prevalence of pediatric Type-2 diabetes (T2D) is particularly troubling since there has been a marked increase in frequency. Early intervention can reverse or prevent some of the more serious side-effects of the disease […]

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    Inflammatory Proteins Hold Promise as Early Predictors of Psychosis

    Researchers at Johns Hopkins University published data suggesting that a panel of inflammatory proteins measured in blood may be useful in identifying changes that are characteristic of psychotic conditions. While more research is needed, these markers, including α2M, fibrinogen, IL-6R, SCF, TGFα, TNFR2, IL-8 and MCP-2/CCL8, have potential utility as early predictors of psychosis and […]

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