Blog « Myriad RBM
 
  • Subscribe to our Blog

  • Categories

  •  

    The Importance of Sample Handling and Curation

    Careful sample handling is critical to maintaining the long term value of legacy samples. Strict protocols and processes are essential to the curation of samples for future study. http://www.genengnews.com/gen-articles/managing-the-past-for-future-benefit/5193/

    » Read this post


    A New Generation of Biomarkers for Detecting Early Signs of Kidney Damage

    Nephrotoxicity is a major problem in the preclinical and clinical setting that results in the failure of candidate compounds throughout the drug-development cycle. An article in this month’s GEN outlines the development of a new generation of biomarkers for drug-induced toxicity that provides greater sensitivity and earlier detection than previous methods. http://www.genengnews.com/gen-articles/fighting-kidney-toxicity-the-case-for-better-biomarkers/5178/

    » Read this post


    S100A12 (EN-RAGE) Correlates with Poor Outcome after Ischemic Stroke

    Researchers published data illustrating the potential utility of S100A12 (EN-RAGE) as a predictive biomarker of functional outcome after ischemic stroke. While further studies are needed, increased plasma levels of EN-RAGE were shown to correlate significantly with increased risk of poor functional outcome. http://www.sciencedirect.com/science/article/pii/S0022510X14001361

    » Read this post


    Biomarkers of Concussion May Speed Diagnosis

    Traumatic brain injuries and concussions are rather common in contact sports, resulting in a variety of symptoms including dizziness, headaches, nausea, and sometimes loss of consciousness. The long-term effects of concussions are still being studied but researchers believe that cumulative blunt force trauma over a career may result in serious neurological conditions later in life. […]

    » Read this post


    Establishing the boundaries of a healthy immune response

    New research published in Immunity describes a standardized method to reproducibly measure a functional immune response in healthy donors. Conducted by researchers at the Institut Pasteur, the study defines protein signatures of the healthy immune response to several relevant stimuli, including common pathogenic microorganisms, defined host sensor agonists, clinically employed cytokines, and activators of T-cell […]

    » Read this post


    Biomarkers for Alzheimer’s Continue to Offer Hope

    As the population ages and the number of individuals diagnosed with Alzheimer’s rises, there is an ever increasing need for earlier diagnosis. Detecting the disease before dementia sets in may be the only hope for therapies set to stave off the cognitive decline associated with it. Nature Medicine recently published data from a longitudinal study […]

    » Read this post


    Fibrinogen Identified as a Prognostic Biomarker for Malignant Pleural Mesothelioma (MPM)

    MPM is a treatment-resistant disease pathogenically related to chronic inflammation. Research recently published in the British Journal of Cancer concludes that fibrinogen measured in the plasma of patients with MPM prior to treatment provides clinical utility as an independent biomarker capable of predicting treatment outcomes. While more investigation is needed, the identification of a prognostic […]

    » Read this post


    Biomarkers Validated for Acute Kidney Injury (AKI)

    A clinical test measuring tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) in urine has been validated to identify patients at risk for impending AKI. http://www.ncbi.nlm.nih.gov/pubmed/24559465

    » Read this post


    CSF Biomarkers Measure Tissue Damage Indicative of Disease Activity in Multiple Sclerosis (MS)

    A recent study shows that three CSF markers, MBP, NFL and GFAp, can measure ongoing damage of oligodendrocytes, axons and astrocytes in patients with MS. This capability can be used to improve current methods of evaluating disease activity. http://onlinelibrary.wiley.com/doi/10.1111/ane.12239/abstract;jsessionid=0BC1364DCBA7F0E3E8C0754031C4D61F.f03t04

    » Read this post


    New Biomarker Offers Hope for Early Detection of Cardiac Injury

    Myocardial infarctions and acute coronary syndrome affect nearly 1 million Americans every year. These events result in damage to the heart tissue and lead to hospitalization with high levels of morbidity and mortality. Cardiac troponin is a biomarker that is elevated in plasma following these events but it lacks the sensitivity to detect early stage […]

    » Read this post