Renal Function / Toxicity Archives - Myriad RBM
 
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    A New Generation of Biomarkers for Detecting Early Signs of Kidney Damage

    Nephrotoxicity is a major problem in the preclinical and clinical setting that results in the failure of candidate compounds throughout the drug-development cycle. An article in this month’s GEN outlines the development of a new generation of biomarkers for drug-induced toxicity that provides greater sensitivity and earlier detection than previous methods. http://www.genengnews.com/gen-articles/fighting-kidney-toxicity-the-case-for-better-biomarkers/5178/

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    Biomarkers Validated for Acute Kidney Injury (AKI)

    A clinical test measuring tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) in urine has been validated to identify patients at risk for impending AKI. http://www.ncbi.nlm.nih.gov/pubmed/24559465

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    Using Renal Biomarkers to Advance Drug and Diagnostic Development in Kidney Disease

    Read this ebook, published by FierceBiotech, to learn how researchers are using new, more sensitive biomarkers to develop drugs and diagnostics in kidney disease. http://www.fiercebiomarkers.com/offer/renal_biomarkers

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    The Need for Additional Translational Biomarkers

    The authors of this paper review the various methods of safety biomarker discovery and development, and challenge researchers to advance the use of safety biomarkers that are indicative of drug-induced toxicity. This type of research typically spans both preclinical and clinical development programs. Having the ability to identify translational safety biomarkers on the same technology […]

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    New Blood-Based Biomarker Assay for the Early Detection of Kidney Cancer

    Researchers identified a 3-biomarker immunoassay, measuring NNMT, LCP1, and NM23A, that successfully distinguishes healthy patients from those with renal cell carcinoma (RCC). If their results can be validated, physicians would have an unprecedented tool for the early detection and subsequent treatment of this silent and deadly disease.

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    Urinary Biomarkers of Lupus Nephritis

    Researchers at the University of Cincinnati College of Medicine, Ohio State University, and Johns Hopkins have identified several biomarkers of early kidney damage in patients suffering from lupus. Various combinations of the markers, including neutrophil gelatinase-associated lipocalin (NGAL) and monocyte chemotactic protein 1 (MCP-1), along with more traditional kidney markers, were able to accurately predict […]

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    Biomarkers Indicate Acute Kidney Injury following Heart Surgery

    Several biomarkers, including neutrophil gelatinase-associated lipocalin (NGAL) and interleukin-18, were found to be useful in predicting the progression and severity of acute kidney injury after cardiac surgery. Biomarkers such as these which help detect disease at earlier stages are useful to improve the care of patients undergoing these procedures. View Article »

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