Assay Change Log

This page contains an up-to-date list of the important changes to Myriad RBM’s products and assays. These changes are made as part of our ongoing efforts to improve the quality of our assays and the data we provide. We strive to deliver superior services by emphasizing reliable data and aim to make customers aware of information that may impact their projects as soon as possible.

If you have questions about any of the items contained in the following tables, please contact Myriad RBM’s Client Services team

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2014

Assay or Product Description of Change Effective Date
Beta Amyloid1-40 (AB 40)Assay adjusted to meet industry standards.08-Oct-14
Beta Amyloid 1-42 (AB-42)Assay adjusted to meet industry standards.08-Oct-14
Lymphotactin Assay discontinued from all rodent services. 07-Oct-14
Lipocalin-1 (LCN-1) Assay added to human services 07-Oct-14
Assay or Product Description of Change Effective Date
PYY Assay discontinued from all human services. 23-Sep-14
Antithrombin-III Assay added to CardiovascularMAP 05-Sep-14
Ficolin-3 Assay added to CardiovascularMAP 05-Sep-14
Neurpilin-1 Assay added to CardiovascularMAP 05-Sep-14
Neutrophil Activating Peptide 2 Assay added to CardiovascularMAP 05-Sep-14
Pigment Epithelium Derived Factor Assay added to CardiovascularMAP 05-Sep-14
Serum Amyloid A Protein Assay added to CardiovascularMAP 05-Sep-14
Thrombin-Activatable Fibrinolysis Assay added to CardiovascularMAP 05-Sep-14
Osteopontin Assay removed from CardiovascularMAP 05-Sep-14
Glucagon Assay discontinued from all human services 05-Sep-14
Receptor tyrosine-protein kinase erbB-3 Assay did not meet specifications in EDTA plasma 05-Sep-14
Fatty Acid-Binding Protein, adipocyte Assay did not meet specifications in serum 05-Sep-14
Galectin-3 Assay redeveloped using new antibody pair 05-Sep-14
All human products Assay ranges updated 28-Aug-14
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Multiplex buffer composition adjusted. 27-Aug-14
Interferon gamma (IFN-gamma) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-10 (IL-10) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-18 (IL-18) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-2 (IL-2) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-3 (IL-3) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-4 (IL-4) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-5 (IL-5) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-6 (IL-6) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-7 (IL-7) Multiplex buffer composition adjusted. 27-Aug-14
Interleukin-8 (IL-8) Multiplex buffer composition adjusted. 27-Aug-14
Macrophage Inflammatory Protein-1 alpha (MIP-1 alpha) Multiplex buffer composition adjusted. 27-Aug-14
Macrophage Inflammatory Protein-1 beta (MIP-1 beta) Multiplex buffer composition adjusted. 27-Aug-14
Monocyte Chemotactic Protein 1 (MCP-1) Multiplex buffer composition adjusted. 27-Aug-14
Tumor Necrosis Factor alpha (TNF-alpha) Multiplex buffer composition adjusted. 27-Aug-14
Tumor Necrosis Factor beta (TNF-beta) Multiplex buffer composition adjusted. 27-Aug-14
RANTES Assay discontinued from all rodent services. 16-Aug-14
Vitronectin Assay discontinued from all human services. 15-Aug-14
Human NeuroMAP™ v. 1.0 Product added to human services 08-Aug-14
Cortisol Assay adjusted to meet industry standards. 06-Aug-14
CD 40 antigen (CD40) Multiplex buffer composition adjusted. 04-Aug-14
CD40 Ligand (CD40-L) Multiplex buffer composition adjusted. 04-Aug-14
Erythropoietin (EPO) Assay added to human services 04-Aug-14
Myeloperoxidase (MPO) Assay moved to a different multiplex. 04-Aug-14
Granulocyte Colony-Stimulating Factor (G-CSF) Multiplex buffer composition adjusted. 04-Aug-14
Alpha-Fetoprotein (AFP) Assay adjusted to meet industry standards. 08-Aug-14
Cancer Antigen 125 (CA 125) Assay adjusted to meet industry standards. 04-Aug-14
Antithrombin-III (AT-III) Multiplex buffer composition adjusted. 04-Aug-14
Ficolin-3 Multiplex buffer composition adjusted. 04-Aug-14
Leucine-rich alpha-2-glycoprotein (LRG1) Multiplex buffer composition adjusted. 04-Aug-14
Neutrophil Activating Peptide 2 (NAP-2) Multiplex buffer composition adjusted. 04-Aug-14
Pigment Epithelium Derived Factor (PEDF) Multiplex buffer composition adjusted. 04-Aug-14
Serum Amyloid A Protein (SAP) Multiplex buffer composition adjusted. 04-Aug-14
Thrombin-activable fibrinolysis inhibitor (TAFI) Multiplex buffer composition adjusted. 04-Aug-14
Neuropilin-1 Assay moved to a different multiplex. 04-Aug-14
Assay or Product Description of Change Effective Date
CD40 Assay discontinued from all rodent services 27-June-14
Myeloperoxidase (MPO) Assay discontinued from all rodent services 27-June-14
CD40 Ligand (CD40-L) Assay discontinued from all rodent services 27-June-14
Complement Factor H Related Protein 1 (CFHR1) Assay moved to a different multiplex 20-June-14
Complement Factor H Related Protein 1 (CFHR1) Assay removed from Human DiscoveryMAP 175+, Human DiscoveryMAP 250+ 20-June-14
Canine KidneyMAP Product removed from rodent services 05-June-14
Rat MetabolicMAP Product removed from rodent services 05-June-14
Apolipoprotein C-I (Apo C-I) Assay added to CardiovascularMAP 06-May-14
Chromogranin-A (CgA) Assay added to CardiovascularMAP 06-May-14
Factor VII Assay added to CardiovascularMAP 06-May-14
Fetuin-A Assay added to CardiovascularMAP 06-May-14
Glucagon-like Peptide 1, active (GLP-1 active) Assay added to CardiovascularMAP 06-May-14
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Assay added to CardiovascularMAP 06-May-14
Insulin Assay added to CardiovascularMAP 06-May-14
Interferon gamma (IFN-gamma) Assay added to CardiovascularMAP 06-May-14
Interferon gamma Induced Protein 10 (IP-10) Assay added to CardiovascularMAP 06-May-14
Interleukin-1 alpha (IL-1 alpha) Assay added to CardiovascularMAP 06-May-14
Interleukin-1 beta (IL-1 beta) Assay added to CardiovascularMAP 06-May-14
Interleukin-6 receptor (IL-6r) Assay added to CardiovascularMAP 06-May-14
Interleukin-10 (IL-10) Assay added to CardiovascularMAP 06-May-14
Matrix Metalloproteinase-9 (MMP-9) Assay added to CardiovascularMAP 06-May-14
Serotransferrin (Transferrin) Assay added to CardiovascularMAP 06-May-14
Vascular Endothelial Growth Factor (VEGF) Assay added to CardiovascularMAP 06-May-14
Vitamin K-Dependent Protein S (VKDPS) Assay added to CardiovascularMAP 06-May-14
Adiponectin Assay added to OncologyMAP 06-May-14
Alpha-2-Macroglobulin (A2Macro) Assay added to OncologyMAP 06-May-14
Angiopoietin-2 (ANG-2) Assay added to OncologyMAP 06-May-14
AXL Receptor Tyrosine Kinase (AXL) Assay added to OncologyMAP 06-May-14
Beta-2-Microglobulin (B2M) Assay added to OncologyMAP 06-May-14
Ciliary Neurotrophic Factor (CNTF) Assay added to OncologyMAP 06-May-14
Fas Ligand (FasL) Assay added to OncologyMAP 06-May-14
FASLG Receptor (FAS) Assay added to OncologyMAP 06-May-14
Ferritin (FRTN) Assay added to OncologyMAP 06-May-14
Fibroblast Growth Factor 4 (FGF-4) Assay added to OncologyMAP 06-May-14
Insulin Assay added to OncologyMAP 06-May-14
Interleukin-6 receptor (IL-6r) Assay added to OncologyMAP 06-May-14
Monocyte Chemotactic Protein 3 (MCP-3) Assay added to OncologyMAP 06-May-14
Plasminogen Activator Inhibitor 1 (PAI-1) Assay added to OncologyMAP 06-May-14
Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) Assay added to OncologyMAP 06-May-14
TNF-Related Apoptosis-Inducing Ligand Receptor 3 (TRAIL-R3) Assay added to OncologyMAP 06-May-14
Transforming Growth Factor beta-3 (TGF-beta-3) Assay added to OncologyMAP 06-May-14
Tumor necrosis factor receptor 2 (TNFR2) Assay added to OncologyMAP 06-May-14
Vascular Cell Adhesion Molecule-1 (VCAM-1) Assay added to OncologyMAP 06-May-14
Rat KidneyMAP v. 1.0 Product removed from rodent services 06-May-14
Bio-Plex Pro™ RBM Rat Kidney Toxicity Service Product added to rodent services 06-May-14
Factor VII Assay discontinued from all rodent products 06-May-14
Adrenomedullin Assay added to human services 06-May-14
Beta Amyloid 1-40 Assay added to human services 06-May-14
Beta Amyloid 1-42 Assay added to human services 06-May-14
Dopamine beta-hydroxylase Assay added to human services 06-May-14
Heat-Shock protein 70 Assay added to human services 06-May-14
Neurofilament heavy polypeptide Assay added to human services 06-May-14
Protein DJ-1 Assay added to human services 06-May-14
HE4 Assay redeveloped using new antibody pair. 01-May-14
CA 72-4 Assay discontinued from all human products 03-Apr-14
Assay Description of Change Effective Date
AACT Assay redeveloped using new antigen. 27-Mar-14
Apolipoprotein A4 Assay redeveloped using new antigen. 27-Mar-14
HSP60 Assay redeveloped using new antigen. 27-Mar-14
Proinsulin (Total) Assay redeveloped using new antigen. 27-Mar-14
Proinsulin (Intact) Assay redeveloped using new antigen. 27-Mar-14
Midkine Assay discontinued from all human services. 27-Mar-14
TIE-1 Assay discontinued from all human products. 20-Mar-14
Urokinase-type Plasminogen Activator (uPA) This assay did not meet performance specifications in EDTA-plasma and results should be used for information purposes only. 10-Mar-14
Lipocalin 1 (LCN1) Assay discontinued from all human products. 28-Feb-14
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) Assay redeveloped using new antibody pair. 28-Feb-14
tPA Assay redeveloped using new antibody pair. 28-Feb-14
Pulmonary and Activation-Regulated Chemokine Assay moved to a different multiplex. 24-Jan-14
Matrix Metalloproteinase-2 (MMP2) Assay moved to a different multiplex. 24-Jan-14
EN-RAGE Assay moved to a different multiplex and now meets performance specifications in both serum and EDTA-plasma. 24-Jan-14
MHC class I chain-related protein A (MICA) Assay moved to a different multiplex. 23-Jan-14
Apolipoprotein B (Apo B) Multiplex buffer composition adjusted. 14-Jan-14
CD5 Antigen-like (CD5L) Multiplex buffer composition adjusted. 14-Jan-14
Clusterin (CLU) Assay dilution adjusted. 14-Jan-14
Complement factor H-related protein 1 (CFHR1) Multiplex buffer composition adjusted. 14-Jan-14
Fetuin A Multiplex buffer composition adjusted. 14-Jan-14
Growth-regulated protein alpha (GRO-alpha) Assay moved to a different multiplex. 14-Jan-14
Leptin R Assay redeveloped using new antibody pair. 14-Jan-14
Progranulin Assay moved to a different multiplex. 14-Jan-14
Thrombin-activatable fibrinolysis inhibitor (TAFI ) Assay redeveloped using new antibody pair. 14-Jan-14
Vitamin K-Dependent Protein S (VKDPS) Assay redeveloped using new antibody pair. Multiplex buffer composition adjusted. 14-Jan-14
Beta-2-Microglobulin Assay moved to a different multiplex. 13-Jan-14
CD27 antigen Assay added to human services. 13-Jan-14
Clusterin Assay moved to a different multiplex. Assay dilution adjusted. 13-Jan-14
Fibroblast Growth Factor 21 Assay added to human services. 13-Jan-14
Fibroblast Growth Factor 23 Assay added to human services. 13-Jan-14
Insulin-like Growth Receptor Type 1 Assay added to human services. 13-Jan-14
Insulin-like Growth Receptor Type 2 Assay added to human services. 13-Jan-14
Progranulin Assay added to human services. 13-Jan-14
Thymus-Expressed Chemokine Assay added to human services. 13-Jan-14
Tissue Inhibitor of Metalloproteinsases 3 Assay added to human services. 13-Jan-14
Vitronectin Assay moved to a different multiplex. 13-Jan-14
Angiotensinogen (AGT) Assay discontinued from all human products. 09-Jan-14
Apolipoprotein D (Apo D) Assay redeveloped using new antibody pair. 07-Jan-14

2013

Assay Description of Change Effective Date
Tissue Inhibitor of Metalloproteinases 3 (TIMP-3) This assay did not meet performance specifications in Serum and results should be used for information purposes only. 05-Dec-13
Ezrin Assay discontinued from all human products. 02-Dec-13
Malondialdehyde-Modified Low-Density Lipoprotein (MDA-LDL) This assay did not meet performance specifications and has been discontinued. 19-Nov-13
Assay Description of Change Effective Date
Pentraxin-3 (PTX3) This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 25-Sep-13
Assay Description of Change Effective Date
Cadherin-1 (E-CAD) This assay did not meet performance specifications in Serum and results should be used for information purposes only. 26-Apr-13
Pancreatic secretory trypsin inhibitor (TATI) This assay did not meet performance specifications in Serum and results should be used for information purposes only. 26-Apr-13
Tyrosine kinase with Ig and EGF homology domains 1 (Tie-1) This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 26-Apr-13
Alpha-2-Macroglobulin (A2M) This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 26-Apr-13
S100 calcium-binding protein B (S-100B) This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 26-Apr-13
E-selectin This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 26-Apr-13
EN-RAGE This assay did not meet performance specifications in EDTA-Plasma and results should be used for information purposes only. 26-Apr-13
Assay Description of Change Effective Date
Prostate Specific Antigen, total (human) Assay adjusted to meet industry standards. 14-Feb-13
MMP-2 (human) Assay discontinued from all human products. 23-Jan-13
Apo-A1 (human) Updated serum and plasma ranges. Assay adjusted to meet industry standards. 15-Jan-13
NGAL (rodent) Redeveloped using new antibody pair. 15-Jan-13
Angiotensinogen (human) Myriad RBM range under evaluation. 15-Jan-13
MMP-1 (human) Myriad RBM range under evaluation. 15-Jan-13
MMP-7 (human) Myriad RBM range under evaluation. 15-Jan-13
MMP-10 (human) Myriad RBM range under evaluation. 15-Jan-13
MMP-9, total (human) Myriad RBM range under evaluation. 15-Jan-13
Peroxiredoxin-4 (human) Assay discontinued from all human products. 8-Jan-13
Protein S100 A6 (human) Assay discontinued from all human products. 8-Jan-13

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