Biomarker Details - Myriad RBM


Fetuin A or AHSG (Alpha 2- Heremans Schmid Glycoprotein) is an abundant plasma protein and a member of the cystatin superfamily of protease inhibitors. It is expressed by hepatocytes and monocytes/macrophages. Fetuin A is a potent inhibitor of calcification with increased levels associated with atherosclerosis calcification. It plays a role in insulin resistance with increased levels seen in type II diabetics. Fetuin A also plays a role in macrophage inhibition and inflammation. Blood levels of Fetuin A are decreased during injury, infection, and inflammation.

Swiss-Prot Accession Number: P02765

Therapy Indications

Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia (2010) Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, (JM) van Beveren N, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S Biomark Insights5: 39–47.