Interleukin-12 Subunit p70 (IL-12p70)
Interleukin-12 p70 (IL-12p70) is the 70 kDa subunit of IL-12. It is produced mainly by B-cells and to a lesser extent by T-cells. The most powerful inducers of IL-12 are bacteria, bacterial products, and parasites. It has been shown to augment natural killer-cell mediated cytotoxicity in a number of conditions, including patients with hairy cell leukemia, and it has been shown to inhibit the growth of a variety of experimental tumors in vivo. IL-12 also has anti-angiogenic effects in vivo, which are in part, mediated by IFN-gamma. IL-12 is potential candidate for the treatment of angiogenesis-dependent malignancies.
Swiss-Prot Accession Number: P29459