Interleukin-12 Subunit p70
Interleukin-12 p70 (IL-12p70) is the 70 kDa subunit of IL-12. It is produced mainly by B-cells and to a lesser extent by T-cells. The most powerful inducers of IL-12 are bacteria, bacterial products, and parasites. It has been shown to augment natural killer-cell mediated cytotoxicity in a number of conditions, including patients with hairy cell leukemia, and it has been shown to inhibit the growth of a variety of experimental tumors in vivo. IL-12 also has anti-angiogenic effects in vivo, which are in part, mediated by IFN-gamma. IL-12 is potential candidate for the treatment of angiogenesis-dependent malignancies.
Swiss-Prot Accession Number: P29459
Publications Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease
(2012) Huang JF, Yafawi R, Zhang M, McDowell M, Rittenhouse KD, Sace F, Liew SH, Cooper SR, Pickering EH Ophthalmology. 2012 Jul;119(7):e43-50
Sex-specific serum biomarker patterns in adults with Asperger's syndrome
(2010) Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S Mol Psychiatry. 2010 Sep 28. [Epub ahead of print]
"Host Tissue Damage" Signal ATP Impairs IL-12 and IFNgamma Secretion in LPS Stimulated Whole Human Blood.
(2008) Nalos M, Huang S, Sluyter R, Khan A, Santner-Nanan B, Nanan R, McLean AS Intensive Care Med 34: 1891-1897.
Neighboring adipocytes participate in the bone marrow microenvironment of multiple myeloma cells.
(2007) Caers J, Deleu S, Belaid Z, De Raeve H, Van Valckenborgh E, De Bruyne E, Defresne MP, Van Riet I, Van Camp B, Vanderkerken K Leukemia 21: 1580-1584.