Matrix Metalloproteinase-3 « Biomarker Details « Myriad RBM

Matrix Metalloproteinase-3 (MMP-3)

Matrix Metalloproteinase-3 (MMP-3), also termed Stromelysin-1, can degrade numerous extracellular matrix (ECM) substrates such as fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. MMP-3 activates procollagenase and MMP-9. It can also release cell surface molecules such as heparin-binding EGF-like growth factor and TNF-alpha and inactivate several serine proteinase inhibitors.

Swiss-Prot Accession Number: P08254