Biomarker Details - Myriad RBM
 
 

Osteopontin

Osteopontin (OPN) acts as a cytokine and is involved in enhancing the production of interferon-gamma and IL-12 and reducing the production of IL-10. OPN is essential in the pathway that leads to type I immunity. It appears to form an integral part of the mineralized matrix. OPN is synthesized within the kidney and is present in human urine at levels that can effectively inhibit calcium oxalate crystallization. Decreased concentrations of OPN have been documented in the urine from patients with renal stone disease compared with normal individuals.

Swiss-Prot Accession Number: P10451


Publications

Plasma protein biomarkers enhance the clinical prediction of kidney injury recovery in patients undergoing liver transplantation. (2014) Levitsky J, Baker TB, Jie C, Ahya S, Levin M, Friedewald J, Al-Saden P, Salomon DR, Abecassis MM. Hepatology 2014 Jul 31. doi: 10.1002/hep.27346. [Epub ahead of print]

Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space (2013) Ma X, Pietsch J, Wehland M, Schulz H, Saar K, H├╝bner N, Bauer J, Braun M, Schwarzw├Ąlder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Wa├čer K, Grosse J, Infanger M, Grimm D FASEB J. 2013 Nov 6. [Epub ahead of print]

Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3├č signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders

Plasma biomarkers of depressive symptoms in older adults (2012) Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VMY, Mackin RS, Trojanowski JQ, Wilson RS, Shaw LM Translational Psychiatry (2012) 2, e65;

Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients (2012) Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S Translational Psychiatry (2012) 2, e82

Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients (2012) Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S Translational Psychiatry (2012) 2, e82

Host-derived osteopontin maintains an acute inflammatory response to suppress early progression of extrinsic cancer cells (2011) Hsieh YH, Juliana MM, Ho KJ, Kuo HC, van der Heyde H, Elmets C, Chang PL Int J Cancer. 2011 Aug 8. doi: 10.1002/ijc.26359. [Epub ahead of print]