Tumor Necrosis Factor alpha (TNF-alpha)
Tumor Necrosis Factor alpha (TNF-alpha) is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion and is implicated in the induction of cachexia. Under certain conditions it can stimulate cell proliferation and induce cell differentiation. TNF-alpha appears to be an important autocrine modulator promoting the survival of hairy cell leukemia cells. It may be important in the pathogenesis of this disease. Studies with an experimental fibrosarcoma metastasis model have shown that TNF-alpha induces significant enhancement of the number of metastases in the lung.
Swiss-Prot Accession Number: P01375