Vascular Cell Adhesion Molecule-1 (VCAM-1)
Vascular Cell Adhesion Molecule-1 (VCAM-1) supports the adhesion of lymphocytes, monocytes, natural killer cells, eosinophils, and basophils through its interaction with leukocyte very late antigen-4 (VLA-4). The VCAM-1/VLA4 interaction mediates firm adherence of circulating non-neutrophilic leukocytes to endothelium and may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. Soluble VCAM-1 levels have been found in the serum of healthy individuals and increased levels of sVCAM-1 can be detected in many inflammatory diseases.
Swiss-Prot Accession Number: P19320