Clusterin (CLU) is the most widely accepted name for a highly conserved protein that has been identified independently by many different laboratories. Other names for CLU include: SGP2, S35-S45, apolipoprotein J, SP-40, 40, ADHC-9, gp80, GPIII, and testosterone-repressed prostate message (TRPM-2). Clusterin has been associated with the clearance of cellular debris and apoptosis. Other functions include the control of complement-mediated cell lysis, shuttling of aberrant beta-amyloid across the blood-brain barrier and lipid scavenging. The measurement of urinary or serum clusterin may play a role in the early detection of renal injury. Increased urinary levels have been observed in rat models of tubular proteinuria but not glomerular proteinuria.
Swiss-Prot Accession Number: P05371
Publications CD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model
(2014) Lin Y, Manning PT, Jia J, Gaut JP, Xiao Z, Capoccia BJ, Chen CC, Hiebsch RR, Upadhya G, Mohanakumar T, Frazier WA, Chapman WC Transplantation. 2014 Jun 30. [Epub ahead of print]
Urinary cystatin C as a biomarker for diabetic nephropathy and its immunohistochemical localization in kidney in Zucker diabetic fatty (ZDF) rats
(2012) Togashi Y, Miyamoto Y Exp Toxicol Pathol. 2012 Jul 11
Early Urinary and Plasma Biomarkers for Experimental Diabetic Nephropathy
(2012) Alter ML, Kretschmer A, Von Websky K, Tsuprykov O, Reichetzeder C, Simon A, JP Stasch, Hoche B Clin. Lab. 2012;58:659-671
Urinary clusterin, cystatin C, ß2-microglobulin and total protein as markers to detect drug-induced kidney injury
(2010) Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G Nat Biotechnol 28: 463-469.