Interleukin-12 Subunit p70 « Biomarker Details « Myriad RBM
 
 

Interleukin-12 Subunit p70 (IL-12p70)

Interleukin-12 p70 (IL-12p70) is the 70 kDa subunit of IL-12. IL-12 is produced mainly by B-cells and to a lesser extent by T-cells. The most powerful inducers of IL-12 are bacteria, bacterial products, and parasites. It has been shown to augment natural killer-cell mediated cytotoxicity in a number of conditions. The ability of IL-12 to induce the synthesis of IFN-gamma and to stimulate the proliferation of resting peripheral cells may also be of interest. IL-12 has been shown to inhibit the growth of a variety of experimental tumors in vivo and to have anti-angiogenic effects in vivo, which are in part, mediated by IFN-gamma. IL-12 is potential candidate for the treatment of angiogenesis-dependent malignancies.

Swiss-Prot Accession Number: P43431


Publications

Production of LPS-induced inflammatory mediators in murine peritoneal macrophages: neocuproine as a broad inhibitor and ATP7A as a selective regulator (2013) Patel OV, Wilson WB, Qin Z BioMetals, April 2013

A small animal peripheral challenge model of yellow fever using interferon-receptor deficient mice and the 17D-204 vaccine strain (2012) Thibodeaux BA, Garbinoa NC, Lissb NM, Piper J, Blair CD, Roehrig JT Vaccine

Efficient Colonization and Therapy of Human Hepatocellular Carcinoma (HCC) Using the Oncolytic Vaccinia Virus Strain GLV-1h68 (2011) Gentschev I, Müller M, Adelfinger M, Weibel S, Grummt F, Zimmermann M, Bitzer M, Heisig M, Zhang Q, Yu YA, Chen NG, Stritzker J, Lauer UM, Szalay AA PLoS ONE 6(7): e22069

Macrophage-Specific Chemokines Induced via Innate Immunity by Amino Acid Copolymers and Their Role in EAE (2011) Kovalchin J, Krieger J, Genova M, Kawamoto N, Augustyniak M, Collins K, Bloom T, Masci A, Hittinger T, Dufour I, Strominger JL, Zanelli E PLoS ONE 6(12): e26274

Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide. (2008) Iparraguirre A, Tobias JW, Hensley SE, Masek KS, Cavanagh LL, Rendl M, Hunter CA, Ertl HC, von Andrian UH, Weninger W J Leukoc Biol 83: 610-620.

Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. (2008) Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S Dev Biol 322: 302-313.

LXR-dependent gene expression is important for macrophage survival and the innate immune response. (2004) Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P Cell 119: 299-309.