Leukemia Inhibitory Factor (LIF)
Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines, and promotion of megakaryocyte production in vivo. Rat LIF is a 19.9 kDa protein containing 183 amino acid residues that exhibits 91% amino acid sequence identity with murine LIF. LIF is a pleiotropic cytokine required for blastocyst implantation in mice. Uterine expression of LIF, and that of its receptors, has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy.
Swiss-Prot Accession Number: P09056