Leukemia Inhibitory Factor
Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines, and promotion of megakaryocyte production in vivo. Rat LIF is a 19.9 kDa protein containing 183 amino acid residues that exhibits 91% amino acid sequence identity with murine LIF. LIF is a pleiotropic cytokine required for blastocyst implantation in mice. Uterine expression of LIF, and that of its receptors, has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy.
Swiss-Prot Accession Number: P09056
Publications Interleukin-7 aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation
(2012) Hartgring SA, Willis CR, Bijlsma JW, Lafeber FP, van Roon JA Arthritis Res Ther. 2012 Jun 7;14(3):R137
STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
(2011) Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA PLoS ONE 6(7): e22538
Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects.
(2008) Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S Dev Biol 322: 302-313.
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection.
(2006) Knorr CW, Allen SD, Torres AR, Smee DF Antiviral Res 72: 125-133.