von Willebrand factor « Biomarker Details « Myriad RBM
 
 

von Willebrand factor (vWF)

von Willebrand Factor (vWF), also known as ristocetin cofactor, is important in the maintenance of hemostasis. It promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. It also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. vWF is synthesized in endothelial cells and in megakaryocytes as a number of subunits that polymerize and combine with the factor VIII to form a large complex. In the plasma, vWF exists as a heterogenous population of large polymers to which the coagulant factor VIII is complexed by non-covalent bonds. It is an acute-phase reactant.

Swiss-Prot Accession Number: Q8CIZ8


Publications

Effect of ozone exposure and infection on bronchoalveolar lavage: Sex differences in response patterns (2014) Mikerov AN, Phelps DS, Gan X, Umstead TM, Haque R, Wang G, Floros J Toxicol Lett. 2014 Apr 21. pii: S0378-4274(14)00167-2

Cytokines Associated with Increased Erythropoiesis in Sprague-Dawley Rats Administered a Novel Hyperglycosylated Analog of Recombinant Human Erythropoietin (2013) Andrews DA, Hamadeh HK, He YD, Boren BM, Turk JR, Boyce RW, Mytych DT, Barger TE, Salimi-Moosavi H, Sloey B, Elliott S, McElroy P, Sinclair AM, Shimamoto G, Pyrah IT, Lightfoot-Dunn RM Toxicol Pathol. 2013 May 14. [Epub ahead of print]

Cigarette smoke induces molecular responses in respiratory tissues of ApoE-/- mice that are progressively deactivated upon cessation (2013) Boué S, De León H, Schlage WK, Peck MJ, Weiler H, Berges A, Vuillaume G, Martin F, Friedrichs B, Lebrun S, Meurrens K, Schracke N, Moehring M, Steffen Y, Schueller J, Vanscheeuwijck P, Peitsch MC, Hoeng J Toxicology, Available online 1 October 2013

The Innate Immune Response May Be Important For Surviving Plague In Wild Gunnison's Prairie Dogs (2013) Busch JD, Van Andel R, Stone NE, Cobble KR, Nottingham R, Lee J, VerSteeg M, Corcoran J, Cordova J, Van Pelt W, Shuey MM, Foster JT, Schupp JM, Beckstrom-Sternberg S, Beckstrom-Sternberg J, Keim P, Smith S, Rodriguez-Ramos J, Williamson JL, Rocke TE, Wagner DM Journal of Wildlife Diseases 2013 49:4, 920-931

Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia (2012) Pedroso FE, Spalding PB, Cheung MC, Yang R, Gutierrez JC, Bonetto A, Zhan R, Chan HL, Namias N, Koniaris LG, Zimmers TA J Cachexia Sarcopenia Muscle. 2012 Mar 29

Impaired resolution of inflammatory response in the lungs of JF1/Msf mice following carbon nanoparticle instillation (2011) Ganguly K, Upadhyay S, Irmler M, Takenaka S, Pukelsheim K, Beckers J, De Angelis MH, Hamelmann E, Stoeger T, Schulz H Respir Res. Jul 15;12(1):94

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia (2011) Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, Zimmers TA PLoS ONE 6(7): e22538

Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats (2011) Nalabotu SK, Kolli MB, Triest WE, Ma JY, Manne NDPK, Katta A, Addagarla HS, Rice KM, Blough ER International Journal of Nanomedicine Volume 2011:6 Pages 2327 - 2335

Significant growth inhibition of canine mammary carcinoma xenografts following treatment with oncolytic vaccinia virus GLV-1h68 (2010) Gentschev I, Ehrig K, Donat U, Hess M, Rudolph S, Chen N, Yu YA, Zhang Q, Bullerdiek J, Nolte I, Stritzker J, Szalay AA J Oncol. 2010:736907. Epub 2010 Jun 23

Regression of Human Pancreatic Tumor Xenografts in Mice After a Single Systemic Injection of Recombinant Vaccinia Virus GLV-1h68. (2009) Yu YA, Galanis C, Woo Y, Chen N, Zhang Q, Fong Y, Szalay AA Mol Cancer Ther 8: 141-151.