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    Biomarkers for Alzheimer’s Continue to Offer Hope

    As the population ages and the number of individuals diagnosed with Alzheimer’s rises, there is an ever increasing need for earlier diagnosis. Detecting the disease before dementia sets in may be the only hope for therapies set to stave off the cognitive decline associated with it. Nature Medicine recently published data from a longitudinal study […]

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    Fibrinogen Identified as a Prognostic Biomarker for Malignant Pleural Mesothelioma (MPM)

    MPM is a treatment-resistant disease pathogenically related to chronic inflammation. Research recently published in the British Journal of Cancer concludes that fibrinogen measured in the plasma of patients with MPM prior to treatment provides clinical utility as an independent biomarker capable of predicting treatment outcomes. While more investigation is needed, the identification of a prognostic […]

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    Biomarkers Validated for Acute Kidney Injury (AKI)

    A clinical test measuring tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7) in urine has been validated to identify patients at risk for impending AKI. http://www.ncbi.nlm.nih.gov/pubmed/24559465

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    CSF Biomarkers Measure Tissue Damage Indicative of Disease Activity in Multiple Sclerosis (MS)

    A recent study shows that three CSF markers, MBP, NFL and GFAp, can measure ongoing damage of oligodendrocytes, axons and astrocytes in patients with MS. This capability can be used to improve current methods of evaluating disease activity. http://onlinelibrary.wiley.com/doi/10.1111/ane.12239/abstract;jsessionid=0BC1364DCBA7F0E3E8C0754031C4D61F.f03t04

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    New Biomarker Offers Hope for Early Detection of Cardiac Injury

    Myocardial infarctions and acute coronary syndrome affect nearly 1 million Americans every year. These events result in damage to the heart tissue and lead to hospitalization with high levels of morbidity and mortality. Cardiac troponin is a biomarker that is elevated in plasma following these events but it lacks the sensitivity to detect early stage […]

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    Tackling Cancer’s Heterogeneity

    This article from GEN suggests tackling cancer’s heterogeneity using a multipronged approach that includes current advancements in the detection of proteomic biomarkers. The goal is to quantify heterogeneity and assist researchers so that they will be better equipped to determine the marker’s biological roles and shape therapeutic strategies. http://www.genengnews.com/insight-and-intelligence/tackling-cancer-s-heterogeneity-in-2014/77900030/

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    Researchers Identify Signature Protein Biomarkers for Predicting Severity in Flu Cases

    Investigators observed samples from 84 naturally influenza-infected individuals and found increased levels of cytokines MCP-3, IFNa2 and plasma IL-10 predicted progression to more severe flu symptoms. While increased levels of plasma IL-10, MCP-3 and IL-6 levels predicted hospitalization. The findings from this paper also explain why infants are at high risk for complications, and why […]

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    A Digest of the Utility of Inflammatory Biomarkers in Major Depression

    A comprehensive synopsis from Murdoch University reviews the current state of peripheral inflammatory biomarkers and their potential to improve the treatment and diagnosis of major depression. http://researchrepository.murdoch.edu.au/18686/

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    Examining the role inflammatory biomarkers play in an upcoming COPD study

    ¬† This paper outlines the protocol for a clinical study aimed at determining whether roflumilast (a lon-acting inhibitor of the PDE-4 enzyme) can reduce the inflammation present in patients with moderate-to-severe COPD. As part of the study, biomarkers will be used to quantify the effect that roflumilast has on both systemic and pulmonary inflammation. Previous […]

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    Identifying Prognostic Biomarkers for Amyotrophic Lateral Sclerosis

    Using multiplex biomarker analysis, researchers at Penn State University aim to define a panel of prognostic ALS markers. ¬†This study shows the most meaningful results were obtained when combining biomarkers from CSF and plasma, rather than focusing on a single parameter. The combined plasma and CSF panel consists of six markers and accurately predicted the […]

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