Biomarker Details - Myriad RBM

Alpha-1-Microglobulin (A1Micro)

Alpha-1-microglobulin (A1M) is a small globular protein that is synthesized throughout the body, mainly in the liver. A1M is present in the plasma, urine, and cerebrospinal fluid. The protein functions to degrade heme and remove free radicals, thereby protecting cells from oxidative stress.

Swiss-Prot Accession Number: P02760

Therapy Indications

Evaluation of Novel Biomarkers of Nephrotoxicity in Cynomolgus Monkeys Treated with Gentamicin (2016) Gautier J-C, Zhou X, Yang Y, Gury T, Qu Z, Palazzi X, Léonard J-F, Slaoui M, Veeranagouda Y, Guizon I, Boitier E, Filali-Ansary A, van den Berg BHJ, Poetz O, Joos T, Zhang T, Wang J, Detilleux P, Li B Toxicology and Applied Pharmacology

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology

Characterization of Renal Biomarkers for Use in Clinical Trials: Effect of Preanalytical Processing and Qualification Using Samples from Subjects with Diabetes (2015) Brott DA, Furlong ST, Adler SH, Hainer JW, Arani RB, Pinches M, Rossing P, Chaturvedi N Drug Design, Development and Therapy

Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3ß signaling in bipolar patients (2013) Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S Journal of Affective Disorders

Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset (2012) Johnstone D, Milward EA, Berretta R, Moscato P PLoS One. 2012;7(4):e34341

Evaluation of Plasma Proteomic Data for Alzheimer Disease State Classification and for the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease (2012) Llano DA, Devanarayan V, Simon AJ; The Alzheimer’s Disease Neuroimaging Initiative (ADNI) Alzheimer Dis Assoc Disord. 2012 Sep 27