Biomarker Details - Myriad RBM
 
 

Fetuin-A

Fetuin A or AHSG (Alpha 2- Heremans Schmid Glycoprotein) is an abundant plasma protein and a member of the cystatin superfamily of protease inhibitors. It is expressed by hepatocytes and monocytes/macrophages. Fetuin A is a potent inhibitor of calcification with increased levels associated with atherosclerosis calcification. It plays a role in insulin resistance with increased levels seen in type II diabetics. Fetuin A also plays a role in macrophage inhibition and inflammation. Blood levels of Fetuin A are decreased during injury, infection, and inflammation.

Swiss-Prot Accession Number: P02765


 
Therapy Indications
 
Publications

High false-positive rate of a putative biomarker test to aid in the diagnosis of schizophrenia (2016) Wehler CA, Preskorn, SH Journal of Clinical Psychiatry

Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria*American Journal of Nephrology (2016) Brooks ER, Hoppe B, Milliner DS, Salido E, Rim J, Krevitt LM, Olson JB, Price HE, Vural G, Langman CB American Journal of Nephrology

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports

Serum Proteomic Profiling of Major Depressive Disorder (2015) Bot M, Chan MK, Jansen R, Lamers F, Vogelzangs N, Steiner J, Leweke FM, Rothermundt M, Cooper J, Bahn S, Penninx BWJH Translational Psychiatry

Validation of a Blood-Based Laboratory Test to Aid in the Confirmation of a Diagnosis of Schizophrenia (2010) Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, (JM) van Beveren N, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S Biomark Insights5: 39–47.