Biomarker Details - Myriad RBM

Monocyte Chemotactic Protein 4 (MCP-4)

Monocyte Chemotactic Protein 4 (MCP-4; CCL13) is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. MCP-4 is widely expressed, found in small intestine, thymus, colon, lung, trachea, stomach, and lymph node. Low levels are seen in the pulmonary artery smooth muscle cells. MCP-4 is induced by IL-1 and TNF alpha.

Swiss-Prot Accession Number: Q99616


A Sputum Proteomic Signature That Associates with Increased Il-1? Levels and Bacterial Exacerbations of COPD (2016) Damera G, Pham T-H, Zhang J, Ward CK, Newbold P, Ranade K, Sethi S Lung

Variation in Serum Biomarkers with Sex and Female Hormonal Status: Implications for Clinical Tests (2016) Ramsey JM, Cooper JD, Penninx BWJH, Bahn S Scientific Reports